Features
- Pack of 30 tablets
- Contains 400 mg of active SAMe (most important methyl donors in the central nervous system) in each tablet
- S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine
- Involved in numerous biochemical reactions in tissue including the liver, joints and brain
- Required for the biosynthesis of critical neurotransmitters and hormones
List Price: $39.99
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| Product Information |
Product Description
Potent Promoter of Mood and Cognitive Health After at least 18 controlled human trials, published over almost four decades, SAMe is clearly proven to promote healthy mood.5-12 The latest double-blind trial was published in 2010,7,8 and its findings were so impressive that the journal also published an editorial in praise of SAMe.9 This editorial attributed SAMes marked mood benefits to its diverse roles in brain metabolism.9 SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin, and norepinephrine.1,2 SAMe is also essential for the main metabolic pathway that makes PC (phosphatidylcholine), a key cell membrane phospholipid for the nerve cell informational connections (synapses). Myelinationinsulation of the nerve cell extensions to optimize their electrical conductionalso requires SAMe.13 And SAMe is also essential for the brain to produce melatonin, a hormone that regulates healthy sleep patterns.14 Individuals who have mood difficulties often also have problems with memory and other cognitive functions. In a 2010 double-blind trial, SAMe supported cognitive health while promoting healthy mood.10 SAMe supports the metabolism of acetylcholine, a major nerve transmitter that is essential for attention, learning, and memory and for numerous other functions outside the brain.15 Even as SAMe ameliorates mood difficulties, SAMe also has improved energy levels, as found in two other double-blind trials.11,12 Optimal SAMe intakes for mood and cognitive support are 800-1600 mg per day, preferably as divided doses taken between meals. Promotes Joint Comfort and Mobility A minimum 14 controlled clinical trials prove SAMe is consistently effective for the support of joint comfort and mobility.5,16-18 In the longest trial, which lasted two years, 97 subjects received SAMe at 600 mg per day for the first two weeks, followed by 400 mg per day for the remaining period.16 SAMe continued to improve joint health over the entire course of this long trial, and was very well tolerated. Most of the controlled trials for joint health used SAMe at 1200 mg per day.5,17,18 Researchers conducting these trials noted SAMes relative lack of adverse effects and its capacity to continue improving joint comfort and mobility over the entire period of the trial.16-18 A 2002 meta-analysis of pooled clinical trial data5 and a 2011 clinical review19 both concluded SAMe is a premier joint support nutrient. The tissues of the working joint have a matrix of collagen and proteoglycans, large fibrous molecular complexes that give the joint structural stability. SAMes energized active sulfur group supports collagen and proteoglycan formation.20 SAMes active sulfur also supports the bio-synthesis of glutathione, cysteine, and taurine, key components of the joints antioxidant defenses (and of the liver and the body as a whole).21 Protects and Supports the Liver and Intestine The liver makes most of the bodys SAMe, and itself relies heavily on SAMe for its structural and functional integrity.22 The livers SAMe reserves are readily depleted by alcohol consumption,23,24 or by a variety of chemical toxins.25-28 In three human trials,26-28 supplementation with SAMe protected the liver against alcohol or other manmade toxins. These benefits of SAMe are most
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